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The Platelet-Rich Plasma Research Ecosystem: From Mechanistic Insights to Precision Treatment in Knee Osteoarthritis
Posted on: 20-Feb-2026
Platelet-rich plasma (PRP) is now one of the most widely used orthobiologics in musculoskeletal medicine, with knee osteoarthritis (KOA) as its main indication. PRP represents a spectrum of autologous preparations with differing cellular and protein content. In this narrative review, we frame current knowledge as a research ecosystem spanning mechanistic biology, product characterization, randomized controlled trials (RCTs), systematic reviews and meta-analyses, methodological evaluations, expert consensus, and precision medicine.
Source: ScienceDirect
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Efficacy of Platelet Rich Plasma Injection as an Combined Modality in Reducing Pain and Improving Functional Outcome in Plantar Fasciitis - A Randomized Control Trial
Posted on: 20-Feb-2026
Plantar fasciitis is a common cause of chronic heel pain and functional limitation. While most patients respond to conservative treatment, refractory cases have led to increased interest in regenerative therapies such as platelet-rich plasma (PRP). This study evaluates the efficacy of PRP as an adjunct to physiotherapy compared with placebo in chronic plantar fasciitis.
Source: ScienceDirect
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Bone Marrow Aspirate ConcentrateIs Equivalent to Platelet-Rich Plasma for theTreatment of Knee Osteoarthritis at 1 Year
Posted in: Stem Cell Therapy | Posted on: 24-Feb-2020
Background: Approximately 47 million people in the United States have been diagnosed with arthritis. Autologous platelet-richplasma (PRP) injections have been documented to alleviate symptoms related to knee osteoarthritis (OA) in randomized controlledtrials, systematic reviews, and meta-analyses. Autologous bone marrow aspirate concentrate (BMC) injections have also emergedas a treatment option for knee OA, with a limited clinical evidence base.
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Chiropractors and their state boards should stop risky stem cell injections
Posted in: Stem Cell Therapy | Posted on: 07-Feb-2020
There are gray areas within the larger stem cell sphere or as I called it in a recent paper “the stem cell ecosystem“, but chiropractors doing stem cell transplants is not one of them. This is unethical and risky on many levels, but the number of chiropractors selling stem cells is increasing rapidly nonetheless. Chiropractors who are selling stem cells should stop and their organizations should prohibit it. The money involved makes it likely that somehow they will have to be forced to stop.
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Exciting new stem cell research for arthritis and meniscus
Posted in: Stem Cell Therapy | Posted on: 12-Jan-2020
For the treatment of progressive degenerative changes of the knee joint in osteoarthritis, the use of autologous cellular materials has been proposed. The purpose of the study was to investigate the structural changes of the meniscus and the epiphysis of the tibia affected by osteoarthritis after the use of cellular technologies. Materials and methods. The experimental osteoarthritis was modeled in rabbits; after 1 month, platelet plasma, autologous bone marrow aspirate, and homogenized adipose tissue were injected into the knee cavity.
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Sustained Release of Growth Factors from Photoactivated Platelet Rich Plasma (PRP)
Posted on: 11-Dec-2019
The goal of this study is to specify the ability of polychromatic light source (PAC), providing effective wavelengths in the range of 600-1200 nm (near-infrared region, NIR), to activate human platelets in platelet-rich plasma (PRP) and to achieve sustained and controlled release of growth factors from photoactivated platelets.
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Use of Ultrasound-Guided Platelet-Rich Plasma Injection of the Sacroiliac Joint as a Treatment for Chronic Low Back Pain
Posted on: 11-Dec-2019
Back pain and its associated complications are of increasing importance among military members. The sacroiliac joint (SIJ) is a common source of chronic low back pain (LBP) and functional disability. Many patients suffering from chronic LBP utilize opioids to help control their symptoms. Platelet-rich plasma (PRP) has been used extensively to treat pain emanating from many different musculoskeletal origins; however, its use in the SIJ has been studied only on a limited basis.
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Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up
Posted on: 27-Nov-2019
Based on our previous study, the utilization of an ultraviolet light photo-cross-linkable hyaluronic acid (HA) hydrogel integrated with a small molecule kartogenin-encapsulated nanoparticles obtained good reconstruction of osteochondral defects in a rabbit model, indicating the superiority of injectable hydrogel-based scaffolds in cartilage tissue engineering.
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Be a informed patient. Don't trust your care to a amateur!
Posted in: Stem Cell Therapy | Posted on: 27-Nov-2019
Our office gets calls daily from patients confused about all the health care providers offering regenerative medicine and stem cells. Number one question to ask. Is your health care provider a Certified Physician in regenerative medicine? Most patients do not know that this certification exists.. just like any specialty in medicine, there is a certification.. to be certified is not easy and takes a lot of time, training and testing.
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Effects of Stromal Cell-Derived Factor-1α Secreted in DegenerativeIntervertebral Disc on Activation and Recruitment of NucleusPulposus-Derived Stem Cells
Posted in: Stem Cell Therapy | Posted on: 24-Nov-2019
Stromal cell-derived factor-1α (SDF-1α) plays a significant role in mobilizing and recruiting mesenchymal stem cells (MSCs) to thesites of injury. This study investigated the potential of SDF-1α released in the degenerative intervertebral disc (IVD) to activate andrecruit endogenous nucleus pulposus-derived stem cells (NPSCs) for regenerationin situ.
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Bone marrow mesenchymal stem cells in rheumatoid arthritis, spondyloarthritis, and ankylosing spondylitis: problems rather than solutions?
Posted in: Stem Cell Therapy | Posted on: 19-Nov-2019
Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. However, in rheumatoid arthritis (RA) and spondyloarthritis (SpA), subsets of subchondral BM-MSCs might conversely fuel synovitis and enthesitis.
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Be a informed consumer patient
Posted in: Stem Cell Therapy | Posted on: 15-Nov-2019
There are many health care providers( physicians, chiropractors, RNs) around the country talking about stem cell injections. They often give seminars about placenta and amniotic “ stem cell” treatments. Research has shown that most if not all of these products are dead stem cells.
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Stem cells, are the latest trend in many areas of medicine
Posted in: Stem Cell Therapy | Posted on: 14-Nov-2019
Stem cells, are the latest trend in many areas of medicine. In regenerative Orthopaedics we use the power of these stem cells to help promote healing. Our body has many types of stem cells.
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Production of Mesenchymal Stem Cells through Stem Cell Reprogramming
Posted in: Stem Cell Therapy | Posted on: 14-Nov-2019
Abstract
Mesenchymal stem cells (MSCs) possess a broad spectrum of therapeutic applications and have been used in clinical trials. MSCs are mainly retrieved from adult or fetal tissues. However, there are many obstacles with the use of tissue-derived MSCs, such as shortages of tissue sources, difficult and invasive retrieval methods, cell population heterogeneity, low purity, cell senescence, and loss of pluripotency and proliferative capacities over continuous passages.
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A Revised Perspective of Skeletal Stem Cell Biology
Posted in: Stem Cell Therapy | Posted on: 14-Nov-2019
Abstract
Bone-related maladies are a major health burden on modern society. Loss of skeletal integrity and regeneration capacity through aging, obesity, and disease follows from a detrimental shift in bone formation and resorption dynamics. Targeting tissue-resident adult stem cells offers a potentially innovative paradigm in the development of therapeutic strategies against organ dysfunction.
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Stem cells as delivery vehicles for regenerative medicine-challenges and perspectives
Posted in: Stem Cell Therapy | Posted on: 14-Nov-2019
Abstract
The use of stem cells as carriers for therapeutic agents is an appealing modality for targeting tissues or organs of interest. Combined delivery of cells together with various information molecules as therapeutic agents has the potential to enhance, modulate or even initiate local or systemic repair processes, increasing stem cell efficiency for regenerative medicine applications.
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Hardwiring stem cell communication through tissue structure
Posted in: Stem Cell Therapy | Posted on: 14-Nov-2019
Abstract
Adult stem cells across diverse organs self-renew and differentiate to maintain tissue homeostasis. How stem cells receive input to preserve tissue structure and function largely relies on their communication with surrounding cellular and non-cellular elements.
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Native-Osteoarthritic Joint Resident Stem and Progenitor Cells for Cartilage Cell-Based Therapies: A Quantitative Comparison With Respect to Concentration and Biological Performance
Posted in: Stem Cell Therapy | Posted on: 14-Nov-2019
Background: Cell-based therapy for cartilage repair is a promising approach and is becoming an established technique. Yet, there is no consensus on the optimal cell source.
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Regenerating Health
Posted in: Stem Cell Therapy | Posted on: 14-Nov-2019
What if you could put your own body to work healing itself? That’s the basic premise of regenerative medicine, which is being used in various ways to restore damaged tissues and speed the body’s healing process.

Regenerative medicine - which uses cells to create living, functioning tissue - holds the promise of repairing damaged tissues and organs by stimulating these tissues to heal themselves, according to the National Institutes of Health.
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The effects of the use of platelet-rich plasma gel on local recurrence in an animal model of human fibrosarcoma
Posted on: 02-Sep-2019
Abstract
Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regeneration and the repair of tissues through the action of the platelet-derived growth factors.
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