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  • PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

    Implant-associated infection is becoming more and more challenging to the healthcare industry worldwide due to increasing antibiotic resistance, transmission of antibiotic resistant bacteria between animals and humans, and the high cost of treating infections.

    In this study, we disclose a new strategy that may be effective in preventing implant-associated infection based on the potential antimicrobial properties of platelet-rich plasma (PRP). Due to its well-studied properties for promoting healing, PRP (a biological product) has been increasingly used for clinical applications including orthopaedic surgeries, periodontal and oral surgeries, maxillofacial surgeries, plasticsurgeries, sports medicine, etc.

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  • Relief for millions as back pain is CURED by a single injection

    The injection of bone marrow into the spine offers hope to millions left in daily agony.

    And the breakthrough could also boost the economy by saving more than

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  • Partial Regeneration of the Human Hip Via Autologous Bone Marrow Nucleated Cell transfer: A Case Study

    History: This is a case report of a 64- year-old white male with a 20 year histo - ry of unilateral hip pain that had become debilitating over the last several years. On intake, Harris hip score was rated as: Pain subscale=10, Function subscale=32, Deformity subscale=4, Motions sub - scale=4.775 with a total score of 50.8 out of 100. MRI of the affected hip showed se - vere degeneration with spurring, decrease in joint space, and several large subchon - dral cysts. The patient had been evaluated by an orthopedic surgeon and told he was a candidate for bipolar hip replacement.

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  • Ultrasound-guided platelet-rich plasma injections for the treatment of common peroneal nerve palsy associated with multiple ligament injuries of the knee

    Abstract

    Peroneal nerve palsy in traumatic knee dislocations associated with multiple ligament injuries is common. Several surgical approaches are described for this lesion with less-than-optimal outcomes. The present case represents the application of plasma rich in growth factors (PRGF) technology for the treatment of peroneal nerve palsy with drop foot. This technology has already been proven its therapeutic potential for various musculoskeletal disorders. Based on these results, we hypothesized that PRGF could stimulate the healing process of traumatic peroneal nerve palsy with drop foot.

    Methods

    The patient was a healthy 28-year-old man. He suffered peroneal nerve palsy with drop foot after multiple ligament injuries of the knee. PRGF was prepared according to the manufactured instruction. Eleven months after the trauma with severe axonotmesis, serial intraneural infiltrations of PRGF were started using ultrasound guidance. The therapeutic effect was assessed by electromyography (EMG), echogenicity of the peroneal nerve under ultrasound (US) and manual muscle testing.

    Results

    Twenty-one months after the first injection, not complete but partial useful recovery is obtained. He is satisfied with walking and running without orthosis. Sensitivity demonstrates almost full recovery in the peroneal nerve distribution area. EMG controls show complete reinnervation for the peroneus longus and a better reinnervation for the tibialis anterior muscle, compared with previous examinations.

    Conclusion

    Plasma rich in growth factors (PRGF) infiltrations could enhance healing process of peroneal nerve palsy with drop foot. This case report demonstrates the therapeutic potential of this technology for traumatic peripheral nerve palsy and the usefulness of US-guided PRGF.

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  • The Use Of PRP In Degenerative Lesions Of The Knee: Results At 2-year Follow-Up

    Abstract

    The purpose of our study was to determine the efficacy of Platelet-Rich Plasma (PRP) treatment in symptomatic patients with early knee osteoarthritis.

    Material and Methods: We prospectively followed up 80 patients with knee OA (Kellgren-Lawrence classification grade 1-3) for a minimum follow up of 24 months. Mean age of patients was 47.7 years. All patients were treated with 2 intra-articular injections at monthly interval with autologous PRP. Twenty-two of the patients repeated the 2 infiltrations at 6 and 12 months and 25 of the patients repeated the 2 infiltrations at 12 and 18 months, while 33 patients had only the initial 2 infiltrations. Half of the patients included in this study had undergone a previous operative intervention for cartilage lesions; previous cartilage interventions included cartilage shaving and microfracture. KOOS, VAS, Tegner, IKDC and MARX scores were collected at pre-treatment evaluation and at 6, 12, 18 and 24-month follow-up.

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  • Tenogenesis of Equine Peripheral Blood-Derived Mesenchymal Stem Cells: In vitro Versus In vivo

    Tendon injuries are a major cause of orthopaedic injuries, and often compromise the return to the same performance level. In thoroughbreds, tendon and ligament injuries are the most common orthopaedic injuries [1,2], and a large number of event, dressage and show jumping horses [3,4], suffer from tendon pathologies, as well. After an injury, tendons heal with the formation of scar tissue.

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