Stem cells, are the latest trend in many areas of medicine
Stem cells, are the latest trend in many areas of medicine. In regenerative Orthopaedics we use the power of these stem cells to help promote healing. Our body has many types of stem cells.
Blog
Production of Mesenchymal Stem Cells through Stem Cell Reprogramming
Abstract
Mesenchymal stem cells (MSCs) possess a broad spectrum of therapeutic applications and have been used in clinical trials. MSCs are mainly retrieved from adult or fetal tissues. However, there are many obstacles with the use of tissue-derived MSCs, such as shortages of tissue sources, difficult and invasive retrieval methods, cell population heterogeneity, low purity, cell senescence, and loss of pluripotency and proliferative capacities over continuous passages.
A Revised Perspective of Skeletal Stem Cell Biology
Abstract
Bone-related maladies are a major health burden on modern society. Loss of skeletal integrity and regeneration capacity through aging, obesity, and disease follows from a detrimental shift in bone formation and resorption dynamics. Targeting tissue-resident adult stem cells offers a potentially innovative paradigm in the development of therapeutic strategies against organ dysfunction.
Stem cells as delivery vehicles for regenerative medicine-challenges and perspectives
Abstract
The use of stem cells as carriers for therapeutic agents is an appealing modality for targeting tissues or organs of interest. Combined delivery of cells together with various information molecules as therapeutic agents has the potential to enhance, modulate or even initiate local or systemic repair processes, increasing stem cell efficiency for regenerative medicine applications.
Hardwiring stem cell communication through tissue structure
Abstract
Adult stem cells across diverse organs self-renew and differentiate to maintain tissue homeostasis. How stem cells receive input to preserve tissue structure and function largely relies on their communication with surrounding cellular and non-cellular elements.
Native-Osteoarthritic Joint Resident Stem and Progenitor Cells for Cartilage Cell-Based Therapies: A Quantitative Comparison With Respect to Concentration and Biological Performance
Background: Cell-based therapy for cartilage repair is a promising approach and is becoming an established technique. Yet, there is no consensus on the optimal cell source.
Regenerating Health
What if you could put your own body to work healing itself? That’s the basic premise of regenerative medicine, which is being used in various ways to restore damaged tissues and speed the body’s healing process.
Regenerative medicine - which uses cells to create living, functioning tissue - holds the promise of repairing damaged tissues and organs by stimulating these tissues to heal themselves, according to the National Institutes of Health.
The effects of the use of platelet-rich plasma gel on local recurrence in an animal model of human fibrosarcoma
Abstract
Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regeneration and the repair of tissues through the action of the platelet-derived growth factors.
Expressions of Growth Factors in Autologous Derived Platelet-Rich Plasma and Platelet-Poor Plasma; Implication for Tissue Reparation and Wound Healing
Abstract
The growth factors (GFs) released from platelet-rich plasma (PRP) is proposed to modulate vascular reactivity and the inflammatory process. other GFs implicated in the wound healing cascade includes Platelet...
The New Treatment Approach In Knee Osteoarthritis: Efficacy Of Cellular Matrix Combination Of Platelet Rich Plasma With Hyaluronic Acid Versus Two Different Types Of Hyaluronic Acid (Ha) (Prospective, Randomized, Double Blind Control Study)
Abstract
Background: Osteoarthritis pathogenesis is a complex process associated with decreased ability to regenerate cartilage mainly due to lack of physiological vascularization. One of the most commonly affected joints is the knee.
Comparative Analysis Of The Effectiveness And Tolerance Of Intra-articular Injection Of Platelet Rich Plasma Vs Hyaluronic Acid And Non-arthroscopic Joint Lavage In Patientswith Knee Osteoarthritis
Abstract
Background: Knee Osteoarthritis (KOA) is a common condition associated with pain and morbidity. The impact of this pathology makes it necessary to develop new procedures for joint regeneration.
Efficiency of platelet-rich plasma therapy in knee osteoarthritis does not depend on level of cartilage damage
Abstract
Objective Osteoarthritis of the knee is common and often leads to significant physical disability.
Comparison of platelet rich plasma and corticosteroids in the management of lateral epicondylitis: A meta-analysis of randomized controlled trials
Abstract
Objective To compare the clinical efficacy of platelet-rich plasma (PRP) injections with that of corticosteroids in patients with lateral epicondylitis (LE).
Effectiveness of Platelet-Rich Plasma in the Management of Knee Osteoarthritis in a Rural Clinic
Abstract
Background Osteoarthritis (OA) is a degenerative disease causing decreased mobility. Use of autologous platelet-rich plasma (PRP) provides a reparative alternative in the management of OA.
Dextrose injections for failed back surgery syndrome: a consecutive case series
Abstract
Background Patients with chronic low back pain, who do not respond to conservative treatment methods, generally undergo surgical revision operations, and sometimes an undesirable condition called failed back surgery syndrome (FBSS) may be inevitable. Hereby, dextrose is one of the regenerative methods that has gained popularity in the treatment of many musculoskeletal problems, and we aimed to present and evaluate the outcomes of 5% dextrose for the treatment of FBSS.
Treatment of unresolved lower back pain with platelet-rich plasma injections
Abstract
Background Platelet-Rich Plasma (PRP) is a non-invasive modality that has been used to treat musculoskeletal conditions for the past two decades. Based on our research, there were no publications that studied the effect of PRP on unresloved lower back pain. The aim of this study was to report the clinical outcomes of patients who received PRP injections to treat unresolved lower back pain.
Single intra-articular platelet-rich plasma versus corticosteroid injections in the treatment of adhesive capsulitis of the shoulder: a cohort study.
Abstract
Objectives To compare the effects of single intra-articular platelet-rich plasma (PRP) and corticosteroid (CS) injections in patients with adhesive capsulitis (AC) of the shoulder. DESIGN:Patients aged 18-70 years of either sex, diagnosed with AC of shoulder, with < 6 months duration were included.
Injecting autologous platelet rich plasma solely into the knee joint is not adequate in treating geriatric patients with moderate to severe knee osteoarthritis
Abstract
Knee pain caused by osteoarthritis (OA) is commonly seen in geriatric patients. Patients with knee OA are often complicated with joint pain, soreness, and weakness. The injection of autologous platelet rich plasma (aPRP) has been proven to be effective in treating mild knee OA. The effect of injecting aPRP in treating moderate to severe degrees of knee OA remains controversial.
Comparative Study of Local Injection of Platelet Rich Plasma versus Corticosteroids in the Treatment of Lateral Epicondylitis
Abstract
Background Lateral epicondylitis, also known as 'tennis elbow', is a very common condition affecting mainly middle-aged patients that is associated with local tendon pathology, alteration in pain perception and motor impairment. Several approaches to treatment have been proposed, the most frequently used is PRP. Platelet-rich plasma (PRP) is a growing modality for tissue healing, regeneration and has more pain relief lasting effect.
Mechanistic insight into hyaluronic acid and platelet-rich plasma-mediated anti-inflammatory and anti-apoptotic activities in osteoarthritic mice
Abstract
Osteoarthritis (OA) poses a major clinical challenges owing to limited regenerative ability of diseased or traumatized chondrocytes in articular cartilage. Previous studies have determined the individual therapeutic efficacies of hyaluronic acid (HA) and platelet-rich plasma (PRP) on OA; however, the underlying mechanism is still lacking. Therefore, we investigated mechanistic approach of HA+PRP therapy on chondrocyte apoptosis in IL-1β+TNF-α (I+T) treated in vitro OA model, in addition to in vivo anterior cruciate ligament transection-OA mice model.