What if you could put your own body to work healing itself? That’s the basic premise of regenerative medicine, which is being used in various ways to restore damaged tissues and speed the body’s healing process.
Regenerative medicine - which uses cells to create living, functioning tissue - holds the promise of repairing damaged tissues and organs by stimulating these tissues to heal themselves, according to the National Institutes of Health.
Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regeneration and the repair of tissues through the action of the platelet-derived growth factors.
The growth factors (GFs) released from platelet-rich plasma (PRP) is proposed to modulate vascular reactivity and the inflammatory process. other GFs implicated in the wound healing cascade includes Platelet...
Background: Osteoarthritis pathogenesis is a complex process associated with decreased ability to regenerate cartilage mainly due to lack of physiological vascularization. One of the most commonly affected joints is the knee.
Background: Knee Osteoarthritis (KOA) is a common condition associated with pain and morbidity. The impact of this pathology makes it necessary to develop new procedures for joint regeneration.
Objective Osteoarthritis of the knee is common and often leads to significant physical disability.
Objective To compare the clinical efficacy of platelet-rich plasma (PRP) injections with that of corticosteroids in patients with lateral epicondylitis (LE).
Background Osteoarthritis (OA) is a degenerative disease causing decreased mobility. Use of autologous platelet-rich plasma (PRP) provides a reparative alternative in the management of OA.
Background Patients with chronic low back pain, who do not respond to conservative treatment methods, generally undergo surgical revision operations, and sometimes an undesirable condition called failed back surgery syndrome (FBSS) may be inevitable. Hereby, dextrose is one of the regenerative methods that has gained popularity in the treatment of many musculoskeletal problems, and we aimed to present and evaluate the outcomes of 5% dextrose for the treatment of FBSS.
Background Platelet-Rich Plasma (PRP) is a non-invasive modality that has been used to treat musculoskeletal conditions for the past two decades. Based on our research, there were no publications that studied the effect of PRP on unresloved lower back pain. The aim of this study was to report the clinical outcomes of patients who received PRP injections to treat unresolved lower back pain.
Objectives To compare the effects of single intra-articular platelet-rich plasma (PRP) and corticosteroid (CS) injections in patients with adhesive capsulitis (AC) of the shoulder. DESIGN:Patients aged 18-70 years of either sex, diagnosed with AC of shoulder, with < 6 months duration were included.
Knee pain caused by osteoarthritis (OA) is commonly seen in geriatric patients. Patients with knee OA are often complicated with joint pain, soreness, and weakness. The injection of autologous platelet rich plasma (aPRP) has been proven to be effective in treating mild knee OA. The effect of injecting aPRP in treating moderate to severe degrees of knee OA remains controversial.
Background Lateral epicondylitis, also known as 'tennis elbow', is a very common condition affecting mainly middle-aged patients that is associated with local tendon pathology, alteration in pain perception and motor impairment. Several approaches to treatment have been proposed, the most frequently used is PRP. Platelet-rich plasma (PRP) is a growing modality for tissue healing, regeneration and has more pain relief lasting effect.
Osteoarthritis (OA) poses a major clinical challenges owing to limited regenerative ability of diseased or traumatized chondrocytes in articular cartilage. Previous studies have determined the individual therapeutic efficacies of hyaluronic acid (HA) and platelet-rich plasma (PRP) on OA; however, the underlying mechanism is still lacking. Therefore, we investigated mechanistic approach of HA+PRP therapy on chondrocyte apoptosis in IL-1β+TNF-α (I+T) treated in vitro OA model, in addition to in vivo anterior cruciate ligament transection-OA mice model.
To analyze the potential modulatory effect of Cellular Matrix, a new medical device de-signed for the one-step preparation of platelet-rich plasma in presence of hyaluronic acid, on the structure of articular cartilage in patients suffering from knee osteoarthritis using high-field Magnetic Resonance Imaging measurements of longitudinal relaxation time after gadolinium injection.
The increased level of leukocytes in leukocyte- and platelet-rich plasma (L-PRP) may activate NF-κB pathway via interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) delivery to counter the beneficial effects of growth factors on cartilage regeneration. The objective of this study is to substantiated that in vivo.
When oxygen gas (02) is exposed to UV radiation or electricity, such as from lightning, the jolt of energy causes it to form ozone (03)-the gas that gives the air its characteristic fresh smell after a lightning storm. Carrying an extra oxygen atom, ozone gas is much more reactive than the regular oxygen we breathe in air. It breaks down rapidly, which is why you can't buy it bottled or have it shipped to you.
Therapeutic evaluation of all-in-one intra-articular (IA) injections of autologous platelet rich plasma (PRP) combined with hyaluronic acid (HA) for knee degenerative disorders.
The aim of this work is to carry out an economic evaluation of the intra-articular (i.a.) use of the platelet-rich plasma (PRP) therapy in the short period treatment for knee osteoarthritis (OA). Recently the scientific literature has shown the effectiveness of this treatment. The comparator adopted is the Hyaluronic acid (HA) which represents the standard i.a. therapy.
Objectives To assess the efficacy of ultrasound guided injection of platelet rich plasma versus high volume injection in treatment of patellar tendinopathy, in patients not responding to conservative treatment.
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