Abstract
The increased level of leukocytes in leukocyte- and platelet-rich plasma (L-PRP) may activate NF-κB pathway via interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) delivery to counter the beneficial effects of growth factors on cartilage regeneration. The objective of this study is to substantiated that in vivo.
Articular cartilage defects generally do not heal spontaneously because of the poor regenerative capability of this tissue. Numerous attempts have been made to induce cartilage regeneration, including autografts, allografts, and xenografts, in an order to prevent progression of cartilage defects to osteoarthritis.