Tag Archives: Osteoarthritis

Platelet-rich plasma inhibits Wnt/β-catenin signaling in rabbit cartilage cells activated by IL-1β

Abstract Objective: Platelet-rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/β-catenin signaling in rabbit chondrocytes. Methods: Using 3-month-old New Zealand white rabbits, PRP was … Continue reading

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The effect of Hypertonic Dextrose injection on the control of pain associated with knee osteoarthritis

Abstract Introduction: The purpose of this study was to evaluate the effect of dextrose injection on controlling pain associated with knee osteoarthritis. Methods: To achieve the research objectives, available sampling was done using 80 patients with knee osteoarthritis referring to … Continue reading

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Single Platelet-Rich Plasma Injection for Early Stage of Osteoarthritis of the Knee

Abstract: Purpose: The purpose of this study was to determine the safety efficacy and outcomes of platelet-rich plasma (PRP) intra-articular injections for early stages of knee osteoarthritis (OA). Methods: Twenty-five patients affected by grade I and II knee primary OA … Continue reading

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Prolotherapy for Osteoarthritis and Tendinopathy: a Descriptive Review

Abstract: Purpose of Review: Osteoarthritis and overuse tendinopathy are common chronic conditions of high societal and patient burden. The precise etiology of pain and disability in both conditions is multifactorial and not well understood. Patients are often refractory to conservative … Continue reading

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Short-term clinical results of intra-articular PRP injections for early osteoarthritis of the knee

Abstract: Purpose: To assess the short-term results of repeated intra-articular platelet rich plasma (PRP) injections into the knee in patients with early osteoarthritis (OA) and to determine a better treatment protocol. Methods: This is a retrospective study in 191 knees … Continue reading

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Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage

Abstract: Objectives: Autophagy constitutes a defense mechanism to overcome aging and apoptosis in osteoarthritic cartilage. Several cytokines and transcription factors are linked to autophagy and play an important role in the degradative cascade in osteoarthritis (OA). Cell therapy such as … Continue reading

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Proliferative injection therapy for osteoarthritis: a systematic review

Abstract: Purpose: To systematically analyse randomised controlled trials (RCTs) about efficacy and safety of proliferative injection therapy (prolotherapy) for treatment of osteoarthritis (OA). Methods: CENTRAL, Embase and MEDLINE were searched. Two reviewers independently conducted screening and data extraction. RCTs were … Continue reading

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Stem Cells in Bone and Articular Cartilage Tissue Regeneration

Abstract: Multiple factors including trauma, infection, ageing, obesity and tumours result in bone and cartilage defects. The regeneration and functional restoration of bone and cartilage remains a significant clinical challenge. ‘Autologous grafts’ continue to remain the ‘gold standard’ in both … Continue reading

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The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

Abstract: Background: Quite a few randomized controlled trials (RCTs) investigating the efficacy of platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently published. Therefore, an updated systematic review was performed to evaluate the temporal effect of PRP … Continue reading

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Ozone Improves Pain Relief, Function and Quality of Life in Patients with Knee Osteoarthritis: A Prospective Quasi-Experimental Before-After Study

Abstract: Background: The study was conducted to: 1) demonstrate the effectiveness of a treatment protocol with Ozone therapy in pain, function, and quality of life in patients with knee osteoarthritis; and 2) apply Ozone as a conservative treatment option with … Continue reading

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