Monthly Archives: February 2016

Plantar fasciitis: Outcome evaluation of plantar fasciitis treated with PRP against steroid injection

Abstract Plantar fasciitis is the most com mmon cause of heel pain which seems difficult t to treat in its most chronic and severe forms. Earlier treatments, including orthoses, non steroidacial anti-inflammatory drugs, and steroid injections aree paucity of supportive … Continue reading

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Long-term effect of Prolotherapy on symptomatic rotator cuff tendinopathy

Abstract Introduction: The objective of this study was to assess a long-term clinical effect of Prolotherapy on chronic symptomatic rotator cuff tendinopathy. Methods: We conducted a retrospective, uncontrolled study in the outpatient setting with 12 months follow-up. Adults diagnosed clinically … Continue reading

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Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo

Abstract Objective: Lubricin expression in the superficial cartilage will be a crucial factor in the success of carti-lage regeneration. Mesenchymal stem cells (MSCs) are an attractive cell source and theuse of aggregates of MSCs has some advantages in terms of … Continue reading

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Adipose stem cells differentiated chondrocytes regenerate damaged cartilage in rat model of Osteoarthritis

Abstract Transplantation of mesenchymal stem cells (MSCs) or autologous chondrocytes has been shown to repair damages to articular cartilage due to osteoarthritis (OA). However survival of transplanted cells is considerably reduced in the osteoarthritic environment and it affects successful outcome … Continue reading

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Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes.

Abstract BACKGROUND: Platelet-rich plasma (PRP) has recently been postulated as a treatment for osteoarthritis (OA). Although anabolic effects of PRP on chondrocytes are well documented, no reports are known addressing effects on cartilage degeneration. Since OA is characterized by a … Continue reading

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Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration

Abstract Platelet-rich blood derivatives have been widely used in different fields of medicine and stem cell-based tissue engineering. They represent natural cocktails of autologous growth factors, which could provide an alternative for recombinant protein-based approaches. Platelet-rich blood derivatives, such as … Continue reading

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Does platelet-rich plasma have a role in the treatment of osteoarthritis?

Abstract Platelet-rich plasma (PRP) has been generating considerable attention as an intra-articular treatment to alleviate the symptoms of osteoarthritis. Activated platelets release a host of soluble mediators such as growth factors and cytokines, thereby inducing complex interactions that vary across … Continue reading

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Cytokine-release kinetics of platelet-rich plasma according to various activation protocols

Abstract Objectives: This study was conducted to evaluate the cytokine-release kinetics of platelet-rich plasma (PRP) according to different activation protocols. Methods: Two manual preparation procedures (single-spin (SS) at 900 g for five minutes; double-spin (DS) at 900 g for five … Continue reading

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Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis An FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial

Abstract Background: Platelet-rich plasma (PRP) injections have become an intriguing treatment option for osteoarthritis (OA), particularly OA of the knee. Despite the plethora of PRP-related citations, there is a paucity of high-level evidence that is comparable, cohort specific, dose controlled, … Continue reading

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Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration

Abstract Purpose: Bone marrow concentrate (BMC) and platelet-rich plasma (PRP) are used extensively in regenerative medicine. The aim of this study was to determine differences in the cellular composition and cytokine concentrations of BMC and PRP and to compare two … Continue reading

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