Monthly Archives: July 2015

Bone Marrow-derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis

Introduction Knee osteoarthritis (knee OA) is characterised by joint space narrowing, osteophyte formation, and subchondral sclerosis and manifests primarily as joint pain(1), resulting in the physical disability of patients. Around 40% of people over 70 years of age suffer from … Continue reading

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Role of autologous platelet-rich plasma in treatment of long-bone nonunions: a prospective study

Abstract Purpose Fracture union is a complex biological process, which depends upon several systemic and local factors. Disturbance of any of these factors may lead to nonunion of the fracture. These nonunions have a huge impact on quality of life … Continue reading

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Combination therapy with intra-articular injection of mesenchymal stem cells and articulated joint distraction for repair of a chronic osteochondral defect in the rabbit

ABSTRACT The present study investigated intra-articular injection of bone-marrow-derived mesenchymal stem cells (MSCs) combined with articulated joint distraction as treatment for osteochondral defects. Large osteochondral defects were created in the weight-bearing area of the medial femoral condyle in rabbit knees. … Continue reading

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Effect of single injection of Platelet-Rich Plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial

Abstract AIM: Evidence on the effect of Platelet-Rich Plasma (PRP) in treating osteoarthritis (OA) is insufficient. Therefore, the present study compares the effects of a one-time injection of PRP and corticosteroid (CS) as two types of treatment for the patients … Continue reading

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Treatment of Articular Cartilage Injury Using Mesenchymal Stem Cells.

Abstract Articular cartilage lesions can be a debilitating disease resulting in the development of osteoarthritis (OA). In recent years, mesenchymal stem cell (MSC) strategies combined with the microfracture technique are emerging as a powerful tool for cartilage repair. Even though … Continue reading

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Re: Ultrasound-guided platelet-rich-plasma injection for distal biceps tendinopathy

We would like to congratulate Barker et al. for their original article, Ultrasound-guided platelet-rich-plasma injection for distal biceps tendinopathy.1 They describe a group of patients with a relatively uncommon but difficult to treat problem of the elbow. In their introduction, however, … Continue reading

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Chondrogenically Primed Mesenchymal Stem Cell-Seeded Alginate Hydrogels Promote Early Bone Formation in Critically-Sized Defects

Abstract Hypertrophic cartilaginous grafts can be engineered in vitro using bone marrow derived Mesenchymal Stem Cells (MSCs). When such engineered tissues are implanted in vivo they have been shown to induce bone formation by recapitulating aspects of the developmental process … Continue reading

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Treatment of Knee Osteoarthritis with Autologous Expanded Bone Marrow Mesenchymal Stem Cells: 50 Cases Clinical and MRI Results at One Year Follow-Up

Abstract Knee osteoarthritis is one of the most prevalent joint diseases, causing pain, function loss and disability, leading to a progressive cartilage degeneration induced by biochemical changes in its composition. Current available treatments focus on addressing symptoms and joint replacement … Continue reading

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A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain

Abstract OBJECTIVES: Controversy exists regarding the efficacy of ligament prolotherapy in alleviating sacroiliac joint pain. The inconsistent success rates reported in previous studies may be attributed to variability in patient selection and techniques between studies. It was hypothesized that intra-articular … Continue reading

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Stem Cell Therapies for Post-Traumatic Arthritis

Post-traumatic arthritis (PTA) is a common condition that occurs in more than 40% of people who experience significant joint trauma, such as ligament injury, meniscal tear, or intra-articular fracture [1]. PTA is estimated to be responsible for 12% of all … Continue reading

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