Monthly Archives: May 2015

Human somatic stem cell-based therapy for cartilage regeneration

Abstract Clinical investigations using human somatic tissue derived stem cells for a variety of different diseases have been performed. Neural crest-derived stem cells exhibit somatic organization, can contribute to mesenchymal stem/stromal cells (MSCs) (1) and are used for cartilage treatment, … Continue reading

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Platelet-rich plasma increases proliferation of tendon cells by modulating Stat3 and p27 to up-regulate expression of cyclins and cyclin-dependent kinases

Objectives To investigate effects of platelet-rich plasma on tendon cell proliferation and the underlying molecular mechanisms. Materials and methods Platelet-rich plasma was prepared manually by two-step centrifugation. Proliferation was evaluated in cultured rat tendon cells by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay. … Continue reading

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Mesenchymal stem cell therapy for knee osteoarthritis: 5 years follow-up of three patients

Abstract Aim Osteoarthritis is a degenerative joint disease characterized by the destruction of joint cartilage. Mesenchymal stem cells (MSCs) are found in low numbers in normal cartilage, mainly in the superficial layer, acting as repairing agents. In OA, MSCs are … Continue reading

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Strategies to stimulate mobilization and homing of endogenous stem and progenitor cells for bone tissue repair

Abstract The gold standard for the treatment of critical sized bone defects is autologous or allogenic bone graft. This has several limitations including donor site morbidity and the restricted supply of graft material. Cell-based tissue engineering strategies represent an alternative … Continue reading

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In Vivo Kinetics of Mesenchymal Stem Cells Transplanted into the Knee Joint in a Rat Model Using a Novel Magnetic Method of Localization

Abstract We have developed a magnetic system for targeting cells in minimally invasive cell transplantation. Magnetically labeled MSCs (m-MSCs) with nanoscale iron particles can be guided into the desired region by magnetic force from an extracorporeal device. We reported that … Continue reading

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The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial

Abstract Introduction: Low-level laser therapy (LLLT) is thought to have an analgesic effect as well as a biomodulatory effect on microcirculation. This study was designed to examine the pain-relieving effect of LLLT and possible microcirculatory changes measured by thermography in … Continue reading

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Meniscus repair using mesenchymal stem cells – a comprehensive review

Abstract The menisci are a pair of semilunar fibrocartilage structures that play an essential role in maintaining normal knee function. Injury to the menisci can disrupt joint stability and lead to debilitating results. Because natural meniscal healing is limited, an … Continue reading

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Resveratrol rescued the TNF-α-induced impairments of osteogenesis of bone-marrow derived mesenchymal stem cells and inhibited the TNF-α-activated NF-кB signaling pathway

Abstract Resveratrol, trans-3,4′-trihydroxystilbene, is a natural phytoalexin. Its anti-inflammatory activity has attracted more and more attention in clinic over the years for the treatment of inflammatory diseases. However, its effect on bone repair and new bone formation in an inflammatory … Continue reading

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