Osteochondral defects are a frequent cause of knee pain in the population. The majority of the diagnosed cases of osteochondral defects (OCD) are treated with surgical procedures. However, there are emerging alternative and integrative medicine options which have appeared on the horizon. These alternative treatment options are minimally invasive with a significant cost reduction and the potential for an earlier return on function due to a shorter rehabilitation period. The focus of this report will be to demonstrate the efficacy of Ultrasound (US) guided Platelet Rich Plasma (PRP) and Autologous Stem Cell Injections in the treatment of osteochondral Defects.