In vivo clinical and radiological effects of platelet-rich plasma on interstitial supraspinatus lesion: Case series

In vivo clinical and radiological effects of platelet-rich plasma on interstitial supraspinatus lesion: Case series

Abstract

Background:Rotator cuff tear (RCT) is a frequent condition of clinical relevance that can be managed with a symptomatic conservative treatment, but surgery is often needed. Biological components like leukocytes and platelet rich plasma (L-PRP) could represent an alternative curative method for interstitial RCT.

Hypotheses:It has been hypothesized that an ultrasound guided L-PRP injection in supraspinatus interstitial RCT could induce radiological healing.

Material and methods:A prospective case series including 25 patients was performed in order to assess the effect of L-PRP infiltration into supraspinatus interstitial RCTs. Primary outcome was tear size change determined by magnetic resonance imaging arthrogram (MRA) before and 6 months after L-PRP infiltration. Secondary outcomes were Constant score, SANE score, and pain visual analog scale (VAS) after L-PRP infiltration.

Results:Tear volume diminution was statistically significant (P = .007), and a >50% tear volume diminution was observed in 15 patients. A statistically significant improvement of Constant score (P < .001), SANE score (P = .001), and VAS (P < .001) was observed. In 21 patients, Constant score improvement reached the minimal clinical important difference of 10.4 points.

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