Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: Long term outcomes

Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: Long term outcomes

Abstract

Objective: Knee osteoarthritis (OA) is a common, debilitating chronic disease. Prolotherapy is an injection therapy for chronic musculoskeletal pain. Recent 52-week randomized controlled and open label studies have reported improvement of knee OA-specific outcomes compared to baseline status, and blinded saline control injections and at-home exercise therapy (p<0.05). However, long term effects of prolotherapy for knee OA are unknown. We therefore assessed long-term effects of prolotherapy on knee pain, function and stiffness among adults with knee OA.

Design: Post clinical-trial, open-label follow-up study.

Setting: Outpatient; adults with mild-to-severe knee OA completing a 52-week prolotherapy study were enrolled.

Intervention And Outcome Measures: Participants received 3-5 monthly interventions and were assessed using the validated Western Ontario McMaster University Osteoarthritis Index, (WOMAC, 0-100 points), at baseline, 12, 26, 52 weeks, and 2.5 years.

Results: 65 participants (58

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