Freeze-Dried Chitosan-PRP Injectable Surgical Implants for Meniscus Repair: Pilot Feasibility Studies in Ovine Models

Freeze-Dried Chitosan-PRP Injectable Surgical Implants for Meniscus Repair: Pilot Feasibility Studies in Ovine Models

Abstract

Clinical management of meniscus tears often involves partial meniscectomy, which can lead to Osteoarthritis (OA). Meniscus repair augmentation strategies are being developed to compensate for the tissue's limited healing response. The purpose of the study was to assess the feasibility of using implants composed of freeze-dried Chitosan (CS) solubilized in Platelet-Rich Plasma (PRP) to improve meniscus repair in ovine models. Lyophilized formulations containing 1% (w/v) chitosan (degree of deacetylation 82% and number average molar mass 38 kDa), 1% (w/v) trehalose and 42.2 mM calcium chloride were solubilized in autologous PRP and applied to surgically induced meniscus lacerations.

Abstract

Clinical management of meniscus tears often involves partial meniscectomy, which can lead to Osteoarthritis (OA). Meniscus repair augmentation strategies are being developed to compensate for the tissue's limited healing response. The purpose of the study was to assess the feasibility of using implants composed of freeze-dried Chitosan (CS) solubilized in Platelet-Rich Plasma (PRP) to improve meniscus repair in ovine models. Lyophilized formulations containing 1% (w/v) chitosan (degree of deacetylation 82% and number average molar mass 38 kDa), 1% (w/v) trehalose and 42.2 mM calcium chloride were solubilized in autologous PRP and applied to surgically induced meniscus lacerations.

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