Abstract
\nAIM: Evidence on the effect of Platelet-Rich Plasma (PRP) in treating osteoarthritis (OA) is insufficient. Therefore, the present study compares the effects of a one-time injection of PRP and corticosteroid (CS) as two types of treatment for the patients suffering from osteoarthritis. METHODS: In the present randomized double blind clinical trial, the participants who suffered from knee osteoarthritis (Grades II/III), were randomly divided into two groups: intra articular injection of PRP and CS. Knee injury and osteoarthritis outcome score (KOOS), the 20-meter-walk test, active and passive ranges of motions (ROM), flexion contracture, and pain intensity based on Visual Analog Scale (VAS) were assessed before, 2-months, and 6-months after interventions. RESULTS: 41 participants (48 knees) were involved in the research (66.7% women; average age of 61.1 ±7.0 years old). Compared to the group treated with corticosteroid, pain relief (df:6 ,35 ;F=11.0 ;p=0.007), symptom free (df:6 ,35 ;F=23.0 ;p<0.001), activities of daily living (ADL) (df:6 ,35 ;F=10.7 ;p=0.005) and quality of life (df:6 ,35 ;F=5.2 ;p=0.02) in the RPR group were significantly higher, but sporting ability was not different between the 2 groups (df:6 ,35 ;F=0.6 ;p=0.55). PRP prescription was significantly more helpful for relieving patients\' pain (VAS) compared to corticosteroids (df:6,35;F=32.0 ;p,0.001).It\'s also notable that using PRP was more helpful in improving the 20-meter-walk test than corticosteroid treatment (df:6 ,35 ;F=7.4 ;p=0.04) but none of the treatments had any impact on active flexion ROM ØŒpassive flexion ROM and flexion contracture (p>0.05).
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