The paper presents the results of the clinical use of platelet-rich plasma in the treatment of long-term non-healing wounds of various etiologies in patients on inpatient treatment and outpatient monitoring in the department of surgical infections of the State-financed health institution, City clinical hospital No. 13, Moscow Health Department, from 2011 to 2016: test group and control group of 50 patients per each, comparable by gender, age, nature of pathology and area of wounds. When analyzing the data obtained, it was found that a significant reduction in the duration of patients treatment was achieved in the test group: the average epithelialization time for the wounds was 42.3 ± 5.7 days, while in the control group, this index was many times higher and averaged 123.8 ± 25.3 days. The average length of hospitalization at the stage of the treatment of patients in the test group was 8.4 ± 1.5 days, in the control group it was 18.1 ± 1.6 days (p < 0.0001). The economic effect averaged 736.81 Euro in savings per patient.